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One means of classifying them is by tissue of origin:
A) Plasma-derived: inactive precursors produced in the liver and circulate as plasma proteins. Activated by binding specific substances which then triggers proteolysis of the next plasma protein in sequence. Examples include:
1. Kinin system.
2. Clotting system.
3. Fibrinolytic system.
4. Complement cascade.
B) Tissue-derived: a diverse range of substances whose release is triggered by a number of stimuli e.g. direct injury, neurogenic stimuli, immune mechanisms, or other inflammatory mediators. Examples include:
1. Vasoactive amines: histamine and serotonin.
2. Eicosanoids – arachidonic acid metabolites.
3. Acute phase proteins.
4. Platelet-activating factor.
5. Lysosomal constituents.
6. Cytokines.
7. Growth factors.