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Chemical mediators of inflammation are substances that are responsible for many of the inflammatory events. According to their origin, they are either plasma-derived or cell-derived. Most mediators perform their job by binding to specific receptors on target cells. One mediator can stimulate the relRead more
Chemical mediators of inflammation are substances that are responsible for many of the inflammatory events. According to their origin, they are either plasma-derived or cell-derived. Most mediators perform their job by binding to specific receptors on target cells. One mediator can stimulate the release of other mediators. The secondary mediators may have identical or similar actions to the initial mediators but may have opposing activities.
The functions of chemical mediators of inflammation include:
See less– **Stimulating release and mediation of target cells themselves:** The secondary mediators have similar or opposite effects.
– **Chemical action:** One or many target cells with different effects.
– **Scavenging oxygen species**.
– **Causing tissue damage:** Histamine and serotonin are examples of mediators that cause tissue damage.