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Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a coccus because it is round, and more specifically a diplocRead more
Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a coccus because it is round, and more specifically a diplococcus because of its tendency to form pairs³. Meningococci have complex nutritional requirements and readily grow in media containing blood or serum, commonly Blood Agar medium, Chocolate Agar medium & Mueller Hinton Agar medium is used for the cultivation of Neisseria meningitidis in the laboratory. They grow best at 35 –36°C and require a moist environment with 5 – 10% CO2 for growth in the laboratory.
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1. Gram-negative intra-cellular diplococci. 2. Neisseria meningitidis (meningococcus) has a prominent polysaccharide capsule that enhances virulence through its complement inhibitory and antiphagocytic action. Nonencapsulated N. meningitidis isolates are generally considered nonpathogenic. The capsuRead more
1. Gram-negative intra-cellular diplococci.
See less2. Neisseria meningitidis (meningococcus) has a prominent polysaccharide capsule that enhances virulence through its complement inhibitory and antiphagocytic action. Nonencapsulated N. meningitidis isolates are generally considered nonpathogenic. The capsule is also the immunogen in the meningococcal vaccine.
3. Serogroups: Based on the antigenic nature of capsular polysaccharides, N. meningitidis can be typed into 13 serogroups (A-D, X-Z, 29E, W135, H-J, and L). Six serogroups (types) of Neisseria meningitidis A, B, C, W, X, and Y cause the majority of cases of IMDs worldwide.
Serotype A was the leading cause of epidemic meningitis worldwide, mainly in the African meningitis belt.