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Mycobacterium tuberculosis has many virulence factors, which can be divided across:
1. Lipid and fatty acid metabolism,
2. Cell envelope proteins,
3. Macrophage inhibitors,
4. Kinase proteins,
5. Proteases,
6. Metal-transporter proteins, and
7. Gene expression regulators.
Some of the virulence factors of Mycobacterium tuberculosis include:
1. Surface-exposed lipids in the mycobacterial outer membrane,
2. Esx family proteins,
3. Pro-Glu (PE)/ Pro-Pro-Glu (PPE) family proteins secreted by type VII secretion systems (T7SS),
4. Alternative sigma factors,
5. Transcriptional repressors and activators,
6. Two-component signaling systems,
7. Metabolic enzymes and
8. Cellular secretory systems.