While blood transfusions are often life-saving, they can also carry certain hazards or risks, ranging from mild to severe. Here's a detailed overview: ⚠️ Hazards of Blood Transfusion 🧪 1. Allergic Reactions - Symptoms: Hives, itching, rash - Cause: Immune response to proteins in donor blood - UsuallRead more
While blood transfusions are often life-saving, they can also carry certain hazards or risks, ranging from mild to severe. Here’s a detailed overview:
⚠️ Hazards of Blood Transfusion
🧪 1. Allergic Reactions
– Symptoms: Hives, itching, rash
– Cause: Immune response to proteins in donor blood
– Usually mild and treatable with antihistamines
🌡️ 2. Febrile Non-Hemolytic Reaction (FNHTR)
– Symptoms: Fever, chills
– Cause: Reaction to white blood cells in transfused blood
– Can be reduced by leucoreduction (removing white cells)
🩸 3. Acute Hemolytic Reaction
– Symptoms: Fever, chills, chest/back pain, dark urine
– Cause: Mismatch in blood type; immune system attacks transfused red cells
– Can lead to kidney damage and is potentially life-threatening
🦠 4. Transmission of Infections
Despite rigorous screening, there’s a very small risk of transmitting:
– HIV (1 in 2 million chance)
– Hepatitis B (1 in 300,000)
– Hepatitis C (1 in 1.5 million)
– West Nile Virus (1 in 350,000)
5. Respiratory Complications
– Includes TRALI (Transfusion-Related Acute Lung Injury)
– Sudden onset of breathing difficulty
– Requires immediate medical attention
🧬 6. Iron Overload
– Occurs in patients receiving multiple transfusions (e.g., thalassemia)
– Excess iron can damage organs like the liver and heart
🧠 7. Immunomodulation
– Transfusion may alter immune response
– Can increase risk of infections, organ dysfunction, and longer hospital stays
Blood groups are classified based on the presence or absence of specific antigens on the surface of red blood cells and antibodies in the plasma. The two most important systems used worldwide are the ABO system and the Rh system, but there are many others recognized for clinical and scientific purpoRead more
Blood groups are classified based on the presence or absence of specific antigens on the surface of red blood cells and antibodies in the plasma. The two most important systems used worldwide are the ABO system and the Rh system, but there are many others recognized for clinical and scientific purposes.
🩸 Major Blood Group Systems
1. ABO Blood Group System
– A: Has A antigens on red cells and anti-B antibodies in plasma.
– B: Has B antigens and anti-A antibodies.
– AB: Has both A and B antigens, no antibodies.
– O: Has no antigens, but both anti-A and anti-B antibodies.
– Most critical for transfusions and organ transplants.
2. Rh (Rhesus) Blood Group System
– Rh Positive (Rh⁺): Has the RhD antigen.
– Rh Negative (Rh⁻): Lacks the RhD antigen.
– Important in pregnancy and transfusion compatibility.
🧬 Other Recognized Blood Group Systems
The International Society of Blood Transfusion (ISBT) recognizes 43 blood group systems, including:
1. MNS- M, N, S, s, U (Involved in transfusion reactions)
See less2. Kell- K, k (Can cause hemolytic disease of the newborn)
3. Duffy- Fya, Fyb (Associated with malaria resistance)
4. Kidd- Jka, Jkb- Important in delayed transfusion reactions)
5. Lutheran- Lua, Lub (Rarely causes transfusion issues)
6. Lewis- Lea, Leb (Found in secretions and plasma)
7. P- P1, Pk (Linked to rare hemolytic reactions)