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Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process. It typically grows from the base of a wound and is able to fill wounds of almost any size. The extracellular matrix of granulation tissue is created and modifiedRead more
Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process. It typically grows from the base of a wound and is able to fill wounds of almost any size. The extracellular matrix of granulation tissue is created and modified by fibroblasts. Initially, it consists of a network of type-III collagen, a weaker form of structural protein that can be produced rapidly. This is later replaced by the stronger, long-stranded type-I collagen, as evidenced in scar tissue.
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