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The fate of red blood cells (RBCs) refers to what happens to them at the end of their life cycle. Here's a short summary: 🩸 Fate of RBCs - Lifespan: RBCs live for about 120 days in circulation. - Senescence: As they age, RBCs lose flexibility and surface proteins change, marking them for removal. -Read more
The fate of red blood cells (RBCs) refers to what happens to them at the end of their life cycle. Here’s a short summary:
🩸 Fate of RBCs
– Lifespan: RBCs live for about 120 days in circulation.
– Senescence: As they age, RBCs lose flexibility and surface proteins change, marking them for removal.
– Destruction:
– Most are phagocytosed by macrophages in the spleen, liver, and bone marrow.
– A small percentage undergo spontaneous hemolysis in circulation.
– Breakdown:
– Hemoglobin is split into heme and globin.
– Globin is broken down into amino acids.
– Heme is converted into biliverdin, then bilirubin, which is excreted via bile.
– Iron from heme is recycled and stored or reused.
This process is essential for maintaining healthy blood composition and preventing the accumulation of damaged cells.
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