Transformation of one differentiated cell type to another differentiated cell type. The change from one type of cell to another may be part of a normal maturation process or caused by some sort of abnormal stimulus. Today, metaplastic changes are usually considered to be an early phase of carcinogenRead more
Transformation of one differentiated cell type to another differentiated cell type. The change from one type of cell to another may be part of a normal maturation process or caused by some sort of abnormal stimulus.
Today, metaplastic changes are usually considered to be an early phase of carcinogenesis, specifically for those with a history of cancers or who are known to be susceptible to carcinogenic changes. Metaplastic change is thus often viewed as a premalignant condition that requires immediate intervention, either surgical or medical, lest it leads to cancer via malignant transformation.
Reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune system and these reactions may be damaging, uncomfortable, or occasionally fatal. Hypersensitivity reactions require a pre-sensitized (immune) state ofRead more
Reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune system and these reactions may be damaging, uncomfortable, or occasionally fatal. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The Gell and Coombs classification of hypersensitivity is the most widely used and distinguishes four types of immune response that result in bystander tissue damage.
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