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Primary wound healing, or primary intention wound healing, occurs in wounds with dermal edges that are close together. It is usually faster than secondary intention and occurs in four stages: Haemostasis, Inflammation, Proliferation, and Remodelling. In Haemostasis, the action of platelets and cytokRead more
Primary wound healing, or primary intention wound healing, occurs in wounds with dermal edges that are close together. It is usually faster than secondary intention and occurs in four stages: Haemostasis, Inflammation, Proliferation, and Remodelling. In Haemostasis, the action of platelets and cytokines forms a hematoma and causes vasoconstriction, limiting blood loss in the affected area. The close proximity of the wound edges allows for ease of clot formation and prevents infection by forming a scab. In Inflammation, a cellular inflammatory response acts to remove any cell debris and pathogens present. In Proliferation, cytokines released by inflammatory cells drive the proliferation of fibroblasts and the formation of granulation tissue. Angiogenesis is promoted by the presence of growth mediators, allowing for further maturation of the granulation tissue; the production of collagen by fibroblasts allows for the closure of the wound after around a week. In Remodelling, collagen fibers are deposited within the wound to provide strength in the region, with the fibroblasts subsequently undergoing apoptosis.
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Secondary wound healing occurs when the sides of the wound are not opposed, therefore healing must occur from the bottom of the wound upwards. It occurs in the same four stages as primary intention: Haemostasis, Inflammation, Proliferation, and Remodelling. In Haemostasis, a large fibrin mesh forms,Read more
Secondary wound healing occurs when the sides of the wound are not opposed, therefore healing must occur from the bottom of the wound upwards. It occurs in the same four stages as primary intention: Haemostasis, Inflammation, Proliferation, and Remodelling. In Haemostasis, a large fibrin mesh forms, which fills the wound. In Inflammation, an inflammatory response acts to remove any cell debris and pathogens present. In Proliferation, cytokines released by inflammatory cells drive the proliferation of fibroblasts and the formation of granulation tissue. Angiogenesis is promoted by the presence of growth mediators, allowing for further maturation of the granulation tissue; the production of collagen by fibroblasts allows for the closure of the wound after around a week. In Remodelling, collagen fibres are deposited within the wound to provide strength in the region, with the fibroblasts subsequently undergoing apoptosis.
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